Matt Cullen

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Biography

I graduated with a Bachelors of Science degree in Chemistry from the University of California, Irvine in 2003, after which I entered the Medicinal Chemistry and Molecular Pharmacology doctoral program at Purdue University.  While at Purdue, my dissertation work involved the design and synthesis of hydrolytically stable analogues of alkenyldiarylmethane-(ADAM) based non-nucleoside HIV-1 reverse transcriptase inhibitors.  As part of my doctoral work I also tried to elucidate the HIV-1 reverse transcriptase-independent antiviral mechanism through which some of the ADAMs operate.  Upon receiving my doctorate in the summer of 2007 I joined the Denmark group as a postdoctoral researcher, where I am now attempting to develop catalytic asymmetric ‘homoaldol’ reactions of cyclopropanone acetals.

Publications

1. Deng, B.-L.; Cullen, M. D.; Zhou, Z.; Hartman, T. L.; Buckheit, R. W.; Pannecouque, C.; De Clercq, E.; Fanwick, P. E.; Cushman, M. Synthesis and anti-HIV activity of new alkenyldiarylmethane (ADAM) non-nucleoside reverse transcriptase inhibitors (NNRTIs) incorporating benzoxazolone and benzisoxazole rings. Bioorg. Med. Chem. 2006, 14, 2366-2374.

2. Sakamoto, T.; Cullen, M. D.; Hartman Tracy, L.; Watson, K. M.; Buckheit Robert, W.; Pannecouque, C.; De Clercq, E.; Cushman, M. Synthesis and Anti-HIV Activity of New Metabolically Stable Alkenyldiarylmethane Non-Nucleoside Reverse Transcriptase Inhibitors Incorporating N-Methoxy Imidoyl Halide and 1,2,4-Oxadiazole Systems. J. Med. Chem. 2007, 50, 3314-3321.

3. Cullen, M. D.; Deng, B. L.; Hartman, T. L. Watson, K. M.; Buckheit, R. W.; Pannecouque, C.; De Clercq, E.; Cushman, M. Synthesis and biological evaluation of alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors that possess increased hydrolytic stability. J. Medicinal Chemistry. 2007. In Press

4. Cullen, M. D.; Deng, B. L.; Casmiro-Garcia; A.; Micklatcher, M. L.; Silvestri, M.; Cheung, Y-F.; Houslay, M.; Cushman, M. Inhibition of phosphodiesterase 4B2 enzymatic activity by alkenyldiarylmethanes HIV-1 non-nucleoside reverse transcriptase inhibitors and implications for their anti-HIV efficacy. Bioorg. Med. Chem. Lett. 2007. Under Review.

5. Cullen, M. D.; Hamel, E.; Cushman, M. Discovery of two potent alkenyldiarylmethane-based inhibitors of tubulin polymerization. Bioorg. Med. Chem. Lett. 2007. Under Review.

6. Cullen, M. D.; Hartman, T. L.; Watson, K. M.; Buckheit, R. W.; Pannecouque, C.; De Clercq, E.; Cushman, M. Crystallography provide insight on the binding interactions of alkenyldiarylmethanes with the HIV-1 Reverse Transcriptase Non-Nucleoside Inhibitor Binding Pocket. J. Med. Chem. 2007. Submission Pending.
    

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