Aldol Chemistry

1. Investigations on Transition State Geometry in the Aldol Condensation (with B. R. Henke) J. Am. Chem. Soc. 1989, 111, 8032-8034.[pdf]
    
2. Investigations on Transition State Geometry in the Aldol Condensation (with B. R. Henke) J. Am. Chem. Soc. 1991, 113, 2177-2194.[pdf]
    
3. Investigations on Transition State Geometry in the Aldol Condensation in Aqueous Medium (with W. Lee) Tetrahedron Lett. 1992, 33, 7729-7732.[pdf]
    
4. The Chemistry of Enoxysilacyclobutanes: Highly Selective, Uncatalyzed Aldol Additions (with B. D. Griedel and D. M. Coe) J. Org. Chem. 1993, 58, 988-990.[pdf]
    
5. Investigations on Transition-State Geometry in the Lewis Acid- (Mukaiyama) and Fluoride-Promoted Aldol Reaction (with W. Lee) J. Org. Chem. 1994, 59, 707-709.[pdf]
    
6. Triarylcarbenium Ions as Catalysts in the Mukaiyama Aldol Addition: A Mechanistic Investigation (with C.-T. Chen) Tetrahedron Lett. 1994, 35, 4327-4330.[pdf]
    
7. The Chemistry of Enoxysilacyclobutanes: Highly Selective Uncatalyzed Aldol Additions (with B. D. Griedel, D. M. Coe and M. E. Schnute) J. Am. Chem. Soc. 1994, 116, 7026-7043.[pdf]
    
8. The Chemistry of Enoxysilacyclobutanes. 3. Uncatalyzed, Syn-Selective, Asymmetric Aldol Additions (with B. D. Griedel) J. Org. Chem. 1994, 59, 5136-5138.[pdf]
    
9. The Chemistry of Trichlorosilyl Enolates. 1. New Reagents for Catalytic Asymmetric Aldol Additions (with S. B. D. Winter, X. Su and K.-T. Wong) J. Am. Chem. Soc. 1996, 118, 7404-7405.[pdf]
    
10. The Chemistry of Trichlorosilyl Enolates. 2. Highly-Selective Asymmetric Aldol Additions of Ketone Enolates (with K.-T. Wong and R. A. Stavenger) J. Am. Chem. Soc. 1997, 119, 2333-2334.[pdf]
     
11. The Chemistry of Chlorosilyl Enolates. 3. Variation of the Silyl Group and the Effect on Rate and Enantiomeric Excess of Acetate Aldol Additions (with S. B. D. Winter) Synlett 1997, 1087-1089.[pdf]
     
12. Lewis Base-Catalyzed, Asymmetric Aldol Additions of Methyl Ketone Enolates (with R. A. Stavenger and K.-T. Wong) J. Org. Chem. 1998, 63, 918-919.[pdf]
     
13. Asymmetric Aldol Additions Catalyzed by Chiral Phosphoramides: Electronic Effects of the Aldehyde Component (with R. A. Stavenger and K.-T. Wong) Tetrahedron 1998, 54, 10389-10402.[pdf]
     
14. Asymmetric Catalysis with Chiral Lewis Bases (with R. A. Stavenger, X. Su, K.-T. Wong and Y. Nishigaichi) Pure Appl. Chem. 1998, 70, 1469-1476.
    [pdf]
     
15. Preparation of Chlorosilyl Enolates (with R. A. Stavenger, S. B. D. Winter, K.-T. Wong and P. A. Barsanti) J. Org. Chem. 1998, 63, 9517-9523.[pdf]
     
16. Highly 1,4-syn Diastereoselective, Phosphoramide-Catalyzed Aldol Additions of Chiral Methyl Ketone Enolates (with R. A. Stavenger) J. Org. Chem. 1998, 63, 9524-9527.[pdf]
     
17. The Chemistry of Trichlorosilyl Enolates. 6. Mechanistic Duality in the Lewis Base-Catalyzed Aldol Addition Reaction (with X. Su and Y. Nishigaichi) J. Am. Chem.Soc. 1998, 120, 12990-12991.[pdf]
     
18. Chiral Phosphoramide-Catalyzed Aldol Additions of Ketone Enolates. Preparative Aspects (with R. A. Stavenger, K.-T. Wong and X. Su) J. Am. Chem. Soc. 1999, 121, 4982-4991.[pdf]
     
19. Solid State and Solution Structural Studies of Chiral Phosphoramide-Tin Complexes Relevant to Lewis Base Catalyzed Aldol Addition Reactions (with X. Su) Tetrahedron 1999, 55, 8727-8738.[pdf]
     
20. Asymmetric Catalysis of Aldol Reactions with Chiral Lewis Bases (with R. A. Stavenger) Accounts Chem. Res. 2000, 33, 432-440.[pdf]
     
21. Kinetic Analysis of the Divergence of Reaction Pathways in the Chiral Lewis Base Promoted Aldol Addition of Trichlorosilyl Enolates: A Rapid Injection NMR Study (with S. M. Pham) Helv. Chim. Acta 2000, 83, 1846-1853.
    [pdf]
     
22. The Chemistry of Trichlorosilyl Enolates. Aldol Addition Reactions of Methyl Ketones (with R. A. Stavenger) J. Am. Chem. Soc. 2000, 122, 8837-8847.[pdf]
     
23. Diastereoselective Aldol Addition Reactions of a Chiral Methyl Ketone Trichlorosilyl Enolate under Lewis Base Catalysis (with S. Fujimori), Synlett 2001, SI, 1024-1029.[pdf]
     
24. Highly Diastereoselective Aldol Additions of a Chiral Ethyl Ketone Enolate Under Lewis Base Catalysis (with S. M. Pham) Org. Lett. 2001, 3, 2201-2204.
    [pdf]
     
25. The First Catalytic, Diastereoselective, and Enantioselective Crossed-Aldol Reactions of Aldehydes (with S. Ghosh) Angew. Chem. Int. Ed. 2001, 40, 4759-4762.[pdf]
     
26. Catalytic, Enantioselective Aldol Additions to Ketones (with Y. Fan) J. Am. Chem. Soc. 2002, 124, 4233-4235.[pdf]
     
27. Diastereoselective Aldol Additions of Chiral beta -Hydroxy Ethyl Ketone Enolates Catalyzed by Lewis Bases (with S. Fujimori) Org. Lett. 2002, 4, 3473-3476.[pdf]
     
28. The Effects of a Remote Stereogenic Center in the Lewis Base Catalyzed Aldol Additions of Chiral Trichlorosilyl Enolates (with S. Fujimori) Org. Lett. 2002, 4, 3477-3480.[pdf]
     
29. Lewis Base Activation of Lewis Acids. Addition of Silyl Ketene Acetals to Aldehydes (with T. Wynn, G. Beutner) J. Am. Chem. Soc. 2002, 124, 13405-13407.[pdf]
     
30. Lewis Base Activation of Lewis Acids. Catalytic Enantioselective Addition of Silyl Enol Ethers of Achiral Methyl Ketones to Adehydes (with Jr. Heemstra Jr.) Org. Lett. 2003. 5, 2303-2306.[pdf]
     
31. Stereoselective Aldol Additions of Achiral Ethyl Ketone-Derived Trichlorosilyl Enolates (with S. Pham) J. Org. Chem. 2003, 68, 5045-5055.[pdf]
     
32. Lewis Base Activation of Lewis Acids. Vinylogous Aldol Reactions (with G. Beutner) J. Am. Chem. Soc. 2003, 125, 7800-7801.[pdf]
     
33. The First Catalytic, Asymmetric alpha-Additions of Isocyanides. Lewis-Base-Catalyzed, Enantioselective Passerini-Type Reactions (with Y. Fan) J. Am. Chem. Soc. 2003, 125, 7825-7827.[pdf]
     
34. Chiral Phosphoramide-Catalyzed, Enantioselective, Directed Cross-Aldol Reactions of Aldehydes (with T. Bui) Proc. Nat. Acad. Sci. 2004, 101, 5439-5444.[pdf]
     
35. 4S-(4a,5b)]-1-(1,3-Dimethyl-2-oxido-4,5-diphenyl-1,3,2-
    diazaphospholidine-2-yl)piperidine (with S. M. Pham) e-EROS Encyclopedia of Reagents for Organic Synthesis [Online] 2002.
     
36. Lewis Base Activation of Lewis Acids: Vinylogous Aldol Additions of Dienol Ethers to Aldehydes (with J. R. Heemstra Jr.) Synlett 2004, 13, 2411-2416.[pdf]
     
37. Lewis Base Activiation of Lewis Acids: Catalytic, Enantioselective Addition of Silyl Ketene Acetals to Aldehydes (with G. L. Beutner, T. Wynn, and M. D. Eastgate) J. AM. Chem. Soc. 2005, 127, 3774-3789.[pdf]
     
38. Lewis Base Catalyzed Enantioselective Aldol Addition of Methyl Trichlorosilyl Ketene Acetal to Ketones (with Y. Fan and M. D. Eastgate) J. Org. Chem. 2005, 70, 5235-5248.[pdf]
     
39. Total Synthesis of RK-397 (with S. Fujimori) J. Am. Chem. Soc. 2005, 127, 8971-8973.[pdf]
     
40. Catalytic, Enantioselective, Vinylogous Aldol Reactions (with J. R. Heemstra Jr. and G. L. Beutner) Angew. Chem. Int. Ed. 2005, 44, 4682-4698.[pdf]
     
41. Catalytic, Enantioselective alpha-Additions of Isocyanides: Lewis-Base-Catalyzed Passerini- Type Reactions (with Y. Fan) J. Org. Chem. 2005, 70, 9667-9676.[pdf]
     
42. Lewis Base-Catalyzed Enantioselective Aldol Addition of Acetaldehyde-Derived Silyl Enol Ether to Aldehydes (with T. Bui) J. Org. Chem. 2005, 70, 10190-10193.[pdf]
     
43. Mechanistic Insights into the Chiral Phosphoramide-Catalyzed, Enantioselective Crossed-Aldol Reactions of Aldehydes (with T. Bui) J. Org. Chem. 2005, 70, 10393-10393.[pdf]
     

44. Base Catalyzed Aldol Additions of Chiral Trichlorosilyl Enolates and Silyl Enol Ethers (with J. Fujimori and S. M. Pham) J. Org. Chem. 2005, 70, 10823-10840.[pdf]

45. Lewis Base Activation of Lewis Acids. Vinylogous Aldol Addition Reactions of Conjugated N,O­-Silyl Ketene Acetals to Aldehydes (with J. R. Heemstra, Jr.) J. Am. Chem. Soc.2006, 128, 1038-1039.  [pdf]

46. Chiral Phosphoramide-Catalyzed Aldol Additions of Ketone Trichlorosilyl Enolates. Mechanistic Aspects (with S. M. Pham, R. A. Stavenger, X. Su, K.-T. Wong, and Y. Nishigaichi) J. Org. Chem. 2006, 71, 3904-3922. [pdf]
    
    
47. Unexpected Ambidoselectivity in Crossed-Aldol Reaction of a-Oxy Aldehyde Trichlorosilyl Enolates (with S. K. Ghosh) Tetrahedron: Yamamoto Prize 2006 Special Issue 2007, 63, 8636-8644. [pdf]
    
    
48. Lewis Base Activation of Lewis Acids: Catalytic, Enantioselective Vinylogous Aldol Addition Reactions (with J. R. Heemstra Jr.) J. Org. Chem. 2007, 72, 5668-5688. [pdf]
    


49. Enantioselective Construction of Quaternary Stereogenic Carbons by the Lewis Base Catalyzed Additions of Silyl Ketene Imines to Aldehydes (with T. W. Wilson, M. T. Burk, and J. R. Heemstra, Jr.) J. Am. Chem. Soc. 2007, 129, 14864-14865. [pdf]


50. Investigations into Transition-State Geometry in the Mukaiyama Directed Aldol Reaction (with W. Lee) Chem. Asian J. 2008, 321-341. [pdf]


51. Lewis Base Activation of Lewis Acids: Catalytic Enantioselective Glycolate Aldol Reactions (with Won-jin Chung) Angew. Chem. Int. Ed. 2008, 47, 1890-1892. [pdf]


52. Methyl Trichlorosilyl Ketene Acetal (with Y. Fan) e-EROS Encyclopedia of Reagents for Organic Synthesis [DOI: 10.1002/047084289X.rn00824] 2008. [pdf]


53. Lewis Base Activation of Lewis Acids: Catalytic, Enantioselective Addition of Glycolate-Derived Silyl Ketene Acetals to Aldehydes (with W. Chung) J. Org. Chem. 2008, 73, 4582-4595. [pdf]

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